ChemicalBook > CAS DataBase List > Fmoc-Leu-OH

Fmoc-Leu-OH

Product Name
Fmoc-Leu-OH
CAS No.
35661-60-0
Chemical Name
Fmoc-Leu-OH
Synonyms
FMOC-LEU-OH;FMOC-LEU;FMOC-L-LEU-OH;FMOC-LEUCINE;L-LEUCINE-N-FMOC;N-(fluorenyl-9-methoxycarbonyl)leucine;(S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-4-Methylpentanoic acid;F-L-LEU;NPC 15199;FMOC-L-LEU
CBNumber
CB5477829
Molecular Formula
C21H23NO4
Formula Weight
353.41
MOL File
35661-60-0.mol
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Fmoc-Leu-OH Property

Melting point:
152-156 °C(lit.)
alpha 
-26 º (c=1,DMF 24 ºC)
Boiling point:
486.83°C (rough estimate)
Density 
1.2107 (rough estimate)
refractive index 
-25 ° (C=1, DMF)
storage temp. 
Store below +30°C.
solubility 
DMF (Slightly), DMSO (Slightly)
form 
Solid
pka
3.91±0.21(Predicted)
color 
White to Off-White
optical activity
[α]20/D 25±2°, c = 1% in DMF
BRN 
2178254
Stability:
Hygroscopic
InChIKey
CBPJQFCAFFNICX-IBGZPJMESA-N
CAS DataBase Reference
35661-60-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36/37/39-27-26
WGK Germany 
3
HS Code 
2924 29 70
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52011
Product name
Fmoc-Leu-OH
Purity
Novabiochem?
Packaging
25g
Price
$36.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.52011
Product name
Fmoc-Leu-OH
Purity
Novabiochem?
Packaging
100g
Price
$70
Updated
2024/03/01
Sigma-Aldrich
Product number
8.52011
Product name
Fmoc-Leu-OH
Purity
Novabiochem?
Packaging
250g
Price
$162
Updated
2024/03/01
Sigma-Aldrich
Product number
8.52011
Product name
Fmoc-Leu-OH
Purity
Novabiochem?
Packaging
1kg
Price
$489
Updated
2024/03/01
Sigma-Aldrich
Product number
47633
Product name
Fmoc-Leu-OH
Purity
≥97.0%
Packaging
5G
Price
$32.3
Updated
2024/03/01
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Fmoc-Leu-OH Chemical Properties,Usage,Production

Description

Fmoc-Leu-OH is isomeric with Fmoc-Ile-OH. Like isoleucine, leucine has branching in the sidechain. The branching is at the gamma carbon instead of the beta carbon as in isoleucine. It is used in chemical and peptide syntheses.

Chemical Properties

white to light yellow crystal powde

Uses

Fmoc-L-Leu-OH, is an amino acid derivative, used in peptide chemistry. It is also one of the novel PPARγ ligands that can activate PPARγ in different ways, that reduces osteoclasts differentiation, and thus are better therapeutic targets in diabetes than traditional antidiabetic drugs.

Application

Fmoc-Leu-OH can be used as a reactant to synthesize:
Various oligopeptides by reacting with functionalized α-amino acid hydrochloride salts.
A cyclic depsipeptide sansalvamide A, a natural product found in marine fungus.
Streptocidin A?D, decapeptide antibiotics naturally found in Streptomyces?sp. Tü 6071.
Coumaroyl dipeptide amide that can be used for cosmetic applications.

Preparation

Fmoc-L-leucine is prepared by reacting L-leucine with 9-fluorenylmethoxycarbonyl chloride.

Biological Activity

Anti-inflammatory agent; increases intracellular Ca 2+ levels. PPARγ ligand that induces insulin sensitization, but not adipogenesis.

Fmoc-Leu-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-Leu-OH Suppliers

Americas 1 Belgium 4 Canada 2 China 417 Europe 6 France 3 Germany 9 Hungary 1 India 44 Israel 2 Italy 2 Japan 9 Poland 1 South Korea 1 Switzerland 7 United Kingdom 19 United States 87 Global 615
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View Lastest Price from Fmoc-Leu-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-L-leu-OH 35661-60-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-12-11
Hebei Duling International Trade Co. LTD
Product
FMOC-L-Leucine 35661-60-0
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 tons
Release date
2023-03-07
Wuhan Senwayer Century Chemical Co.,Ltd
Product
Fmoc-Leu-OH 35661-60-0
Price
US $0.00/gram
Min. Order
25gram
Purity
99% HPLC
Supply Ability
25 gram
Release date
2023-10-16

35661-60-0, Fmoc-Leu-OHRelated Search:

L-Leucine N-(9-Fluorenylmethoxycarbonyloxy)succinimide N-CARBOBENZOXY-DL-LEUCINE L-tert-Leucine Glycine Fmoc-Aib-OH 9-Fluorenylmethyl chloroformate FMOC-Ala-OH Fmoc-Lys(Boc)-OH FMOC-N-METHYL-TRANEXAMIC ACID Fmoc-L-Tyr(propargyl)-OH Fmoc-Gly-OH FMOC-O-tert-Butyl-L-serine Fmoc-Asn(Trt)-OH FMOC-TRANEXAMIC ACID Nalpha-Fmoc-Ndelta-trityl-L-glutamine Fmoc-Tyr(tBu)-OH FMOC-METRP-OH

  • FMOC-LEU-OH
  • FMOC-L-LEU-OH
  • FMOC-L-LEU
  • FMOC-L-LEUCINE
  • F-L-LEU
  • Fmoc-L-leucine,98%
  • L-Leucine-1-13C-N-FMOC
  • Fmoc-N-(isobutyl)-glycine
  • N-(fluorenyl-9-methoxycarbonyl)leucine
  • FMOC-L-LEU-OH MONOHYDRATE
  • Fmoc-N-(isobutyl)-Gly-OH
  • FMOC-L-LEUCINE extrapure
  • N-(9-Fluorenylmethoxycarbonyl)-L-leucine, Fmoc-L-leucine
  • 2-(9H-fFuoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine ,98%
  • (2S)-4-Methyl-2-(9H-fluorene-9-ylmethoxycarbonylamino)valeric acid
  • (S)-2-[[(9H-Fluorene-9-yl)methoxycarbonyl]amino]-4-methylpentanoic acid
  • N-[(9H-Fluorene-9-yl)methoxycarbonyl]leucine
  • FMoc-L-leucine FMoc-Leu-OH
  • 2-[[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO]-4-METHYLPENTANOIC ACID
  • 9-FLUORENYLMETHOXYCARBONYL-L-LEUCINE
  • FMOC-LEU
  • FMOC-LEUCINE
  • Fmoc-Leucine-OH
  • FMoc-Nleu-OH
  • N-FMOC-LEU-OH
  • N-FMOC-L-LEU
  • N-FMOC-L-LEUCINE
  • NPC 15199
  • N-ALPHA-FMOC-L-LEUCINE
  • N-(9-FLUORENYLMETHOXYCARBONYL)-L-LEUCINE
  • N-9-FLUORENYLMETHYLOXYCARBONYL-L-LEUCINE
  • N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-LEUCINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-LEUCINE
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-LEUCINE
  • PPAR-GAMMA ACTIVATOR
  • (S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-4-Methylpentanoic acid
  • N-{[(9H-Fluoren-9-yl)methoxy]carbonyl}-L-leucine, (2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanoic acid
  • N-Fmoc-L-leucine Fmoc-Leu-OH
  • FMoc-Leu-OH >=97.0%
  • Fmoc-L-leucin
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Leu-OH
  • Fmoc-L-leucine≥ 99.7% (HPLC, Chiral purity)
  • (2R)-2-amino-3-[4-[4-[(2R)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]phenyl]phenyl]propanoic acid
  • FMOC-LEU-OH 250 G
  • FMOC-LEU-OH 100 G
  • L-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
  • L-LEUCINE-N-FMOC
  • (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoicaci
  • Fmoc-Leu-OH Fmoc-Leu-OH
  • FMOC-L-Leucine USP/EP/BP
  • Fmoc-L-leucine, puriss, 99%
  • N-(9-Fluorenylmethoxycarbonyl)-L-leucine Fmoc-L-leucine 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-methylpentanoic acid N-Fmoc-L-leucine
  • (((9H-fluoren-9-yl)methoxy)carbonyl)-L-leucine
  • 35661-60-0
  • 35661-60-6
  • C21H323NO4
  • CH32CHCH2CHNHFMOCCOOH